Genotoxicity and oxidative stress among spray painter

Several organic solvents (OSs) are potent carcinogens among population at risk. Their genotoxicity have important implications for cancer production. Genotoxicity could be related to lipid peroxidation with decrease of endogenous body antioxidants. This work included 27 car spray painters exposed to a mixture of mainly aromatic OSs and a comparable group of 27 males. For both groups, chromosomal study and assay of serum glutathione peroxidase (GSH-Px) were done. It was found that spray painters suffered a significantly higher percentage of chromosomal aberrations (CAs%) and lower GSH-Px activity specially among smoker ones. Positive correlations were found between CAs% and duration of exposure and the lifetime hydrocarbon exposure score (HES). A significant negative correlation was found between GSH-Px and duration of work and HES. Finally we recommend following up for workers who are at risk of genotoxicity by periodic examination and regular supplementation with antioxidants. [Ehab R. Abdelraouf, Fateheya M. Metwally, Hend Rashad, Saida Hammad. Genotoxicity and oxidative stress among spray painter. Life Science Journal.2012;9(2):20-24] (ISSN: 1097-8135).http://www.lifesciencesite.com. 4